The search process was accomplished through searching databases, such as PubMed, Science Direct, IranMedex, and Irandoc using the keywords of vitamin D in pregnancy, vitamin D deficiency, and clinical trials.

Methods: This systematic review was performed on the Persian and English articles reporting the effect of vitamin D on pregnant women published during 2010-2017. Despite the importance of this issue, there are few studies addressing high doses of vitamin D, such as 50,000 units of vitamin D3.Therefore, this systematic review aimed to investigate the effects of 50,000 units of vitamin D on pregnant women. There is still no clear optimal protocol for the treatment of vitamin D deficiency or for the proper dose of this supplementation and its effects on mothers and infants, which has led to controversies about the safety and effectiveness of vitamin D supplements during pregnancy.

Introduction: Vitamin D deficiency is associated with maternal and fetal complications accordingly, it is of significant importance to investigate the treatment of this deficiency.

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